Prostate Cancer Reports



Volume 3 Number 10
October 2015
Home > Prostate Cancer Reports > Volume 3, Year 2015 > Number 10, October

CONTENTS

PSA-only recurrence after treatment with curative intent (PSAR)

Natural history of biochemical failure

Treatment of PSA-only recurrence after radical prostatectomy

Castration-resistant prostate cancer (CRPC)

First-line treatment of mCRPC




PSA-ONLY RECURRENCE AFTER TREATMENT WITH CURATIVE INTENT

Natural story of biochemical failure

Amling CL, Blute ML, Bergstralh EJ, Seay TM, Slezak J, Zincke H.
Long-term hazard of progression after radical prostatectomy for clinically localized prostate cancer: continued risk ofbiochemical failure after 5 years.
J Urol. 2000 Jul;164(1):101-5.
Article | PubMed abstract | Similar articles


Karl A, Buchner A, Tympner C, Kirchner T, Ganswindt U, Belka C, Ganzer R, Burger M, Eder F, Hofstädter F, Schilling D, Sievert K, Stenzl A, Scharpf M, Fend F, Vom Dorp F, Rübben H, Schmid K, Porres-Knoblauch D, Heidenreich A, Hangarter B, Knüchel-Clarke R, Rogenhofer M, Wullich B, Hartmann A, Comploj E, Pycha A, Hanspeter E, Pehrke D, Sauter G, Graefen M, Stief C, Haese A.
The natural course of pT2 prostate cancer with positive surgical margin: predicting biochemical recurrence.
World J Urol. 2015 Jul;33(7):973-9. doi: 10.1007/s00345-015-1510-y. Epub 2015 Feb 15.
Article | PubMed abstract | Similar articles


Ward JF, Blute ML, Slezak J, Bergstralh EJ, Zincke H.
The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy.
J Urol. 2003 Nov;170(5):1872-6.
Article | PubMed abstract | Similar articles


Treatment of PSAR after radical prostatectomy

Salvage radiotherapy

Bernard JR Jr, Buskirk SJ, Heckman MG, Diehl NN, Ko SJ, Macdonald OK, Schild SE, Pisansky TM.
Salvage radiotherapy for rising prostate-specific antigen levels after radical prostatectomy for prostate cancer: dose-response analysis.
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):735-40. doi: 10.1016/j.ijrobp.2009.02.049. Epub 2009 May 21.-757
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Boorjian SA, Karnes RJ, Crispen PL, Rangel LJ, Bergstralh EJ, Blute ML.
Radiation therapy after radical prostatectomy: impact on metastasis and survival.
J Urol. 2009 Dec;182(6):2708-14. doi: 10.1016/j.juro.2009.08.027.-773
Article | PubMed abstract | Similar articles


Bossi A, De Meerleer G, Ost P.
Intensity-modulated radiotherapy: the gold standard for postprostatectomy irradiation?
Eur Urol. 2011 Dec;60(6):1149-50; discussion 1150-1. doi: 10.1016/j.eururo.2011.08.056. Epub 2011 Sep 7.
Article | PubMed abstract | Full-text PDF | Similar articles  | (Comment on Goenka 2011)


Briganti A, Wiegel T, Joniau S, Cozzarini C, Bianchi M, Sun M, Tombal B, Haustermans K, Budiharto T, Hinkelbein W, Di Muzio N, Karakiewicz PI, Montorsi F, Van Poppel H.
Early salvage radiation therapy does not compromise cancer control in patients with pT3N0 prostate cancer after radical prostatectomy: results of a match-controlled multi-institutional analysis.
Eur Urol. 2012 Sep;62(3):472-87. doi: 10.1016/j.eururo.2012.04.056. Epub 2012 May 16.-774
Article | PubMed abstract | Full-text PDF | Similar articles


Buskirk SJ, Pisansky TM, Schild SE, Macdonald OK, Wehle MJ, Kozelsky TF, Collie AC, Ferrigni RG, Myers RP, Prussak KA, Heckman MG, Crook JE, Parker AS, Igel TC.
Salvage radiotherapy for isolated prostate specific antigen increase after radical prostatectomy: evaluation of prognostic factors and creation of a prognostic scoring system.
J Urol. 2006 Sep;176(3):985-90.-758
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Choo R, Danjoux C, Gardner S, Morton G, Szumacher E, Loblaw DA, Cheung P, Pearse M.
Efficacy of salvage radiotherapy plus 2-year androgen suppression for postradical prostatectomy patients with PSA relapse.
Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):983-9. doi: 10.1016/j.ijrobp.2008.12.049. Epub 2009 May 4.-762
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Cremers RG, van Lin EN, Gerrits WL, van Tol-Geerdink JJ, Kiemeney LA, Vergunst H, Smans AJ, Kaanders JH, Alfred Witjes J.
Efficacy and tolerance of salvage radiotherapy after radical prostatectomy, with emphasis on high-risk patients suited for adjuvant radiotherapy.
Radiother Oncol. 2010 Dec;97(3):467-73. doi: 10.1016/j.radonc.2010.05.023.-756
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Gay HA, Barthold HJ, O'Meara E, Bosch WR, El Naqa I, Al-Lozi R, Rosenthal SA, Lawton C, Lee WR, Sandler H, Zietman A, Myerson R, Dawson LA, Willett C, Kachnic LA, Jhingran A, Portelance L, Ryu J, Small W Jr, Gaffney D, Viswanathan AN, Michalski JM.
Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas.
Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):e353-62. doi: 10.1016/j.ijrobp.2012.01.023. Epub 2012 Apr 6. Erratum in: Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):7.-769
Article | PubMed abstract | Full-text PDF | Similar articles


Goenka A, Magsanoc JM, Pei X, Schechter M, Kollmeier M, Cox B, Scardino PT, Eastham JA, Zelefsky MJ.
Long-term outcomes after high-dose postprostatectomy salvage radiation treatment.
Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):112-8. doi: 10.1016/j.ijrobp.2011.10.077. Epub 2012 Jan 31.-755
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Goenka A, Magsanoc JM, Pei X, Schechter M, Kollmeier M, Cox B, Scardino PT, Eastham JA, Zelefsky MJ.
Improved toxicity profile following high-dose postprostatectomy salvage radiation therapy with intensity-modulated radiation therapy.
Eur Urol. 2011 Dec;60(6):1142-8. doi: 10.1016/j.eururo.2011.08.006. Epub 2011 Aug 12.-771
Article | PubMed abstract | Full-text PDF | Similar articles
| (Comment in Bossi 2011)


King CR.
The timing of salvage radiotherapy after radical prostatectomy: a systematic review.
Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):104-11. doi: 10.1016/j.ijrobp.2011.10.069. Epub 2012 Jul 14.-764
Article | PubMed abstract | Similar articles


King CR, Kapp DS.
Radiotherapy after prostatectomy: is the evidence for dose escalation out there?
Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):346-50. doi: 10.1016/j.ijrobp.2007.10.008. Epub 2008 Jan 30.-765
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Michalski JM, Lawton C, El Naqa I, Ritter M, O'Meara E, Seider MJ, Lee WR, Rosenthal SA, Pisansky T, Catton C, Valicenti RK, Zietman AL, Bosch WR, Sandler H, Buyyounouski MK, Ménard C.
Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancer.
Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):361-8. doi: 10.1016/j.ijrobp.2009.02.006. Epub 2009 Apr 23.-766
Article | PubMed abstract | Full-text PDF | Similar articles


Moul JW.
When should we pull the trigger for post-radical prostatectomy radiotherapy?
Eur Urol. 2012 Sep;62(3):488-90. doi: 10.1016/j.eururo.2012.05.066. Epub 2012 Jun 5.
Article | PubMed abstract | Full-text PDF | Similar articles


Ohri N, Dicker AP, Trabulsi EJ, Showalter TN.
Can early implementation of salvage radiotherapy for prostate cancer improve the therapeutic ratio? A systematic review and regression meta-analysis with radiobiological modelling.
Eur J Cancer. 2012 Apr;48(6):837-44. doi: 10.1016/j.ejca.2011.08.013. Epub 2011 Sep 22.-753
Article | PubMed abstract | Full-text PDF | Similar articles


Ost P, Lumen N, Goessaert AS, Fonteyne V, De Troyer B, Jacobs F, De Meerleer G.
High-dose salvage intensity-modulated radiotherapy with or without androgen deprivation after radical prostatectomy for rising or persisting prostate-specific antigen: 5-year results.
Eur Urol. 2011 Oct;60(4):842-9. doi: 10.1016/j.eururo.2011.04.021. Epub 2011 Apr 16.-772
Article | PubMed abstract | Full-text PDF | Similar articles


Pazona JF, Han M, Hawkins SA, Roehl KA, Catalona WJ.
Salvage radiation therapy for prostate specific antigen progression following radical prostatectomy: 10-year outcome estimates.
J Urol. 2005 Oct;174(4 Pt 1):1282-6.-759
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Pisansky TM, Kozelsky TF, Myers RP, Hillman DW, Blute ML, Buskirk SJ, Cheville JC, Ferrigni RG, Schild SE.
Radiotherapy for isolated serum prostate specific antigen elevation after prostatectomy for prostate cancer.
J Urol. 2000 Mar;163(3):845-50.-760
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Pfister D, Bolla M, Briganti A, Carroll P, Cozzarini C, Joniau S, van Poppel H, Roach M, Stephenson A, Wiegel T, Zelefsky MJ.
Early salvage radiotherapy following radical prostatectomy.
Eur Urol. 2014 Jun;65(6):1034-43. doi: 10.1016/j.eururo.2013.08.013. Epub 2013 Aug 15.-751
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Poortmans P, Bossi A, Vandeputte K, Bosset M, Miralbell R, Maingon P, Boehmer D, Budiharto T, Symon Z, van den Bergh AC, Scrase C, Van Poppel H, Bolla M; EORTC Radiation Oncology Group.
Guidelines for target volume definition in post-operative radiotherapy for prostate cancer, on behalf of the EORTC Radiation Oncology Group.
Radiother Oncol. 2007 Aug;84(2):121-7. Epub 2007 Aug 13.-767
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Sassowsky M, Gut P, Hölscher T, Hildebrandt G, Müller AC, Najafi Y, Kohler G, Kranzbühler H, Guckenberger M, Zwahlen DR, Azinwi NC, Plasswilm L, Takacs I, Reuter C, Sumila M, Manser P, Ost P, Böhmer D, Pilop C, Aebersold DM, Ghadjar P.
Use of EORTC target definition guidelines for dose-intensified salvage radiation therapy for recurrent prostate cancer: results of the quality assurance program of the randomized trial SAKK 09/10.
Int J Radiat Oncol Biol Phys. 2013 Nov 1;87(3):534-41. doi: 10.1016/j.ijrobp.2013.06.2053. Epub 2013 Aug 22.-770
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Siegmann A, Bottke D, Faehndrich J, Brachert M, Lohm G, Miller K, Bartkowiak D, Hinkelbein W, Wiegel T.
Salvage radiotherapy after prostatectomy - what is the best time to treat?
Radiother Oncol. 2012 May;103(2):239-43. doi: 10.1016/j.radonc.2011.10.024. Epub 2011 Nov 25.-752
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Siegmann A, Bottke D, Faehndrich J, Lohm G, Miller K, Bartkowiak D, Wiegel T, Hinkelbein W.
Dose escalation for patients with decreasing PSA during radiotherapy for elevated PSA after radical prostatectomy improves biochemical progression-free survival: results of a retrospective study.
Strahlenther Onkol. 2011 Aug;187(8):467-72. doi: 10.1007/s00066-011-2229-3. Epub 2011 Jul 22.-754
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Soto DE, Passarelli MN, Daignault S, Sandler HM.
Concurrent androgen deprivation therapy during salvage prostate radiotherapy improves treatment outcomes in high-risk patients.
Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1227-32. doi: 10.1016/j.ijrobp.2010.08.030. Epub 2011 May 5.-761
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Stephenson AJ, Scardino PT, Kattan MW, Pisansky TM, Slawin KM, Klein EA, Anscher MS, Michalski JM, Sandler HM, Lin DW, Forman JD, Zelefsky MJ, Kestin LL, Roehrborn CG, Catton CN, DeWeese TL, Liauw SL, Valicenti RK, Kuban DA, Pollack A.
Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy.
J Clin Oncol. 2007 May 20;25(15):2035-41. Erratum in: J Clin Oncol. 2007 Sep 10;25(26):4153.-494
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Valicenti RK, Thompson I Jr, Albertsen P, Davis BJ, Goldenberg SL, Wolf JS, Sartor O, Klein E, Hahn C, Michalski J, Roach M 3rd, Faraday MM; American Society for Radiation Oncology/American Urological Association.
Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association guidelines.
Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):822-8. doi: 10.1016/j.ijrobp.2013.05.029.-763
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Wiegel T, Lohm G, Bottke D, Höcht S, Miller K, Siegmann A, Schostak M, Neumann K, Hinkelbein W.
Achieving an undetectable PSA after radiotherapy for biochemical progression after radical prostatectomy is an independent predictor of biochemical outcome--results of a retrospective study.
Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1009-16. doi: 10.1016/j.ijrobp.2008.06.1922. Epub 2008 Oct 27.-495
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Wiltshire KL, Brock KK, Haider MA, Zwahlen D, Kong V, Chan E, Moseley J, Bayley A, Catton C, Chung PW, Gospodarowicz M, Milosevic M, Kneebone A, Warde P, Ménard C.
Anatomic boundaries of the clinical target volume (prostate bed) after radical prostatectomy.
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1090-9.-768
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Androgen deprivation therapy

Choueiri TK, Xie W, D'Amico AV, Ross RW, Hu JC, Pomerantz M, Regan MM, Taplin ME, Kantoff PW, Sartor O, Oh WK.
Time to prostate-specific antigen nadir independently predicts overall survival in patients who have metastatic hormone-sensitive prostate cancer treated with androgen-deprivation therapy.
Cancer. 2009 Mar 1;115(5):981-7. doi: 10.1002/cncr.24064.-777
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Crook JM, O'Callaghan CJ, Duncan G, Dearnaley DP, Higano CS, Horwitz EM, Frymire E, Malone S, Chin J, Nabid A, Warde P, Corbett T, Angyalfi S, Goldenberg SL, Gospodarowicz MK, Saad F, Logue JP, Hall E, Schellhammer PF, Ding K, Klotz L.
Intermittent androgen suppression for rising PSA level after radiotherapy.
N Engl J Med. 2012 Sep 6;367(10):895-903. doi: 10.1056/NEJMoa1201546. Erratum in: N Engl J Med. 2012 Dec 6;367(23):2262.
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Garcia-Albeniz X, Chan JM, Paciorek AT, Logan RW, Kenfield SA, Cooperberg MR, Caroll P, Hernan M.
Immediate versus deferred initiation of androgen deprivation therapy in prostate cancer patients with PSA-only relapse.
J Clin Oncol, 2014 ASCO Annual Meeting Abstracts. Vol 32, No 15_suppl (May 20 Supplement), 2014: 5003.-779
Article | Meeting abstract


Klayton TL, Ruth K, Buyyounouski MK, Uzzo RG, Wong YN, Chen DY, Sobczak M, Peter R, Horwitz EM.
PSA Doubling Time Predicts for the Development of Distant Metastases for Patients Who Fail 3DCRT Or IMRT Using the Phoenix Definition.
Pract Radiat Oncol. 2011 Oct-Dec;1(4):235-242.
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Moul JW, Wu H, Sun L, McLeod DG, Amling C, Donahue T, Kusuda L, Sexton W, O'Reilly K, Hernandez J, Chung A, Soderdahl D.
Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy.
J Urol. 2004 Mar;171(3):1141-7.-776
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Shahinian VB, Kuo YF, Freeman JL, Orihuela E, Goodwin JS.
Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinoma.
Cancer. 2005 Apr 15;103(8):1615-24.-775
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Shariat SF, Hammerich KH.
Words of wisdom. Re: Timing of androgen deprivation therapy and its impact on survival after radical prostatectomy: a matched cohort study. Siddiqui SA, Boorjian SA, Inman B, Bagniewski S, Bergstralh EJ, Blute ML. J Urol 2008;179:1830-7; discussion 1837.
Eur Urol. 2009 Jan;55(1):245-6.
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Siddiqui SA, Boorjian SA, Inman B, Bagniewski S, Bergstralh EJ, Blute ML.
Timing of androgen deprivation therapy and its impact on survival after radical prostatectomy: a matched cohort study.
J Urol. 2008 May;179(5):1830-7; discussion 1837. doi: 10.1016/j.juro.2008.01.022. Epub 2008 Mar 18.
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CASTRATION-RESISTANT PROSTATE CANCER

First-line treatment of mCRPC

Abiraterone

Rathkopf DE, Smith MR, de Bono JS, Logothetis CJ, Shore ND, de Souza P, Fizazi K, Mulders PF, Mainwaring P, Hainsworth JD, Beer TM, North S, Fradet Y, Van Poppel H, Carles J, Flaig TW, Efstathiou E, Yu EY, Higano CS, Taplin ME, Griffin TW, Todd MB, Yu MK, Park YC, Kheoh T, Small EJ, Scher HI, Molina A, Ryan CJ, Saad F.
Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302).
Eur Urol. 2014 Nov;66(5):815-25. doi: 10.1016/j.eururo.2014.02.056. Epub 2014 Mar 6.
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