Prostate Cancer Reports

Volume 2 Supplement 9
  September 2014

Home > Prostate Cancer Reports > Volume 2 - Year 2014 > Supplement 9, September 2014


Overall recurrence
Biochemical recurrence
Clinical recurrence


Blute ML, Bostwick DG, Bergstralh EJ, Slezak JM, Martin SK, Amling CL, Zincke H.
Anatomic site-specific positive margins in organ-confined prostate cancer and its impact on outcome after radical prostatectomy.
Urology. 1997 Nov;50(5):733-9.
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Chang SN, Han J, Abdelkader TS, Kim TH, Lee JM, Song J, Kim KS, Park JH, Park JH.
High animal fat intake enhances prostate cancer progression and reduces glutathione peroxidase 3 expression in early stages of TRAMP mice.
Prostate. 2014 Sep;74(13):1266-77. doi: 10.1002/pros.22843. Epub 2014 Jul 22.
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La Roca RL, Cunha IW, Bezerra SM, Fonseca FP.
Radical prostatectomy and positive surgical margins: relationship with prostate cancer outcome.
Int Braz J Urol. 2014 May-Jun;40(3):306-15. doi: 10.1590/S1677-5538.IBJU.2014.03.03.
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Pfitzenmaier J, Pahernik S, Tremmel T, Haferkamp A, Buse S, Hohenfellner M.
Positive surgical margins after radical prostatectomy: do they have an impact on biochemical or clinical progression?
BJU Int. 2008 Nov;102(10):1413-8. doi: 10.1111/j.1464-410X.2008.07791.x. Epub 2008 Jun 4.
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Srougi M, Coelho RF, Patel VR. Management of Positive Surgical Margins Following Radical Prostatectomy.
Robotic Urologic Surgery, 2012, pp 215-230, Epub 2011 Jun 17.

Wolters T, Roobol MJ, van Leeuwen PJ, van den Bergh RC, Hoedemaeker RF, van Leenders GJ, Schröder FH, van der Kwast TH.
Should pathologists routinely report prostate tumour volume? The prognostic value of tumour volume in prostate cancer.
Eur Urol. 2010 May;57(5):821-9. doi: 10.1016/j.eururo.2009.07.027. Epub 2009 Jul 29.
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Yossepowitch O, Bjartell A, Eastham JA, Graefen M, Guillonneau BD, Karakiewicz PI, Montironi R, Montorsi F.
Positive surgical margins in radical prostatectomy: outlining the problem and its long-term consequences.
Eur Urol. 2009 Jan;55(1):87-99. doi: 10.1016/j.eururo.2008.09.051. Epub 2008 Oct 1.
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Ha YS, Kang DI, Kim JH, Joung JY, Yu J, Parihar JS, Salmasi AH, Horie S, Kim WJ, Yi Kim I.
Favorable risk factors in patients with positive surgical margin after robot-assisted radical prostatectomy.
Can J Urol. 2014 Jun;21(3):7290-7.
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Gomella LG.
Recommendations for adjuvant post prostatectomy radiation.
Can J Urol. 2014 Jun;21(3):7298.
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Alkhateeb S, Alibhai S, Fleshner N, Finelli A, Jewett M, Zlotta A, Nesbitt M, Lockwood G, Trachtenberg J.
Impact of positive surgical margins after radical prostatectomy differs by disease risk group.
J Urol. 2010 Jan;183(1):145-50. doi: 10.1016/j.juro.2009.08.132. Epub 2009 Nov 13.
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Gleason score 7

Brimo F, Partin AW, Epstein JI.
Tumor grade at margins of resection in radical prostatectomy specimens is an independent predictor of prognosis.
Urology. 2010 Nov;76(5):1206-9. doi: 10.1016/j.urology.2010.03.090. Epub 2010 Aug 8.
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Cho IC, Kwon WA, Kim JE, Joung JY, Seo HK, Chung J, Park WS, Lee KH.
Prostate volume has prognostic value only in pathologic T2 radical prostatectomy specimens.
J Korean Med Sci. 2011 Jun;26(6):807-13. doi: 10.3346/jkms.2011.26.6.807. Epub 2011 May 18.
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Choo MS, Cho SY, Ko K, Jeong CW, Lee SB, Ku JH, Hong SK, Byun SS, Kwak C, Kim HH, Lee SE, Jeong H.
Impact of positive surgical margins and their locations after radical prostatectomy: comparison of biochemical recurrence according to risk stratification and surgical modality.
World J Urol. 2013 Dec 21. [Epub ahead of print]
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D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Schnall M, Tomaszewski JE, Wein A.
A multivariate analysis of clinical and pathological factors that predict for prostate specific antigen failure after radical prostatectomy for prostate cancer.
J Urol. 1995 Jul;154(1):131-8.
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Freedland SJ, Aronson W, Presti JC Jr, Kane CJ, Terris MK, Elashoff D, Amling CL; SEARCH Database Study Group.
Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? Results from the SEARCH database.
J Urol. 2003 Jun;169(6):2142-6.
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Godoy G, Tareen BU, Lepor H.
Site of positive surgical margins influences biochemical recurrence after radical prostatectomy.
BJU Int. 2009 Dec;104(11):1610-4. doi: 10.1111/j.1464-410X.2009.08688.x. Epub 2009 Jun 22.
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Karakiewicz PI, Eastham JA, Graefen M, Cagiannos I, Stricker PD, Klein E, Cangiano T, Schröder FH, Scardino PT, Kattan MW.
Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients.
Urology. 2005 Dec;66(6):1245-50.
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Ko J, Falzarano SM, Walker E, Streator Smith K, Stephenson AJ, Klein EA, Magi-Galluzzi C.
Prostate cancer patients older than 70 years treated by radical prostatectomy have higher biochemical recurrence rate than their matched younger counterpart.
Prostate. 2013 Jun;73(8):897-903. doi: 10.1002/pros.22635. Epub 2012 Dec 31.
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Obek C, Sadek S, Lai S, Civantos F, Rubinowicz D, Soloway MS.
Positive surgical margins with radical retropubic prostatectomy: anatomic site-specific pathologic analysis and impact on prognosis.
Urology. 1999 Oct;54(4):682-8.
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Ohori M, Wheeler TM, Kattan MW, Goto Y, Scardino PT.
Prognostic significance of positive surgical margins in radical prostatectomy specimens.
J Urol. 1995 Nov;154(5):1818-24.
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Palisaar RJ, Graefen M, Karakiewicz PI, Hammerer PG, Huland E, Haese A, Fernandez S, Erbersdobler A, Henke RP, Huland H.
Assessment of clinical and pathologic characteristics predisposing to disease recurrence following radical prostatectomy in men with pathologically organ-confined prostate cancer.
Eur Urol. 2002 Feb;41(2):155-61.
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Rabbani F, Vora KC, Yunis LH, Eastham JA, Guillonneau B, Scardino PT, Touijer K.
Biochemical recurrence rate in patients with positive surgical margins at radical prostatectomy with further negative resected tissue.
BJU Int. 2009 Sep;104(5):605-10. doi: 10.1111/j.1464-410X.2009.08757.x. Epub 2009 Jul 7.
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Resnick MJ, Canter DJ, Guzzo TJ, Magerfleisch L, Tomaszewski JE, Brucker BM, Bergey MR, Sonnad SS, Wein AJ, Malkowicz SB.
Defining pathological variables to predict biochemical failure in patients with positive surgical margins at radical prostatectomy: implications for adjuvant radiotherapy.
BJU Int. 2010 May;105(10):1377-80. doi: 10.1111/j.1464-410X.2009.08953.x. Epub 2009 Nov 3.
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Shikanov S, Marchetti P, Desai V, Razmaria A, Antic T, Al-Ahmadie H, Zagaja G, Eggener S, Brendler C, Shalhav A.
Short (≤ 1 mm) positive surgical margin and risk of biochemical recurrence after radical prostatectomy.
BJU Int. 2013 Apr;111(4):559-63. doi: 10.1111/j.1464-410X.2012.11340.x. Epub 2012 Jul 3.
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Shikanov S, Song J, Royce C, Al-Ahmadie H, Zorn K, Steinberg G, Zagaja G, Shalhav A, Eggener S
Length of positive surgical margin after radical prostatectomy as a predictor of biochemical recurrence.
J Urol. 2009 Jul;182(1):139-44. doi: 10.1016/j.juro.2009.02.139. Epub 2009 May 17.
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Sofer M, Hamilton-Nelson KL, Civantos F, Soloway MS.
Positive surgical margins after radical retropubic prostatectomy: the influence of site and number on progression.
J Urol. 2002 Jun;167(6):2453-6.
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Thompson IM 3rd, Salem S, Chang SS, Clark PE, Davis R, Herrell SD, Kordan Y, Baumgartner R, Phillips S, Smith JA Jr, Cookson MS, Barocas DA.
Tumor volume as a predictor of adverse pathologic features and biochemical recurrence (BCR) in radical prostatectomy specimens: a tale of two methods.
World J Urol. 2011 Feb;29(1):15-20. doi: 10.1007/s00345-010-0611-x. Epub 2010 Nov 16.
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Warner JN, Nunez RN, Mmeje CO, Colby TV, Ferrigni RG, Humphreys MR, Andrews PE, Castle EP.
Impact of margin status at 37 months after robot assisted radical prostatectomy.
Can J Urol. 2011 Dec;18(6):6043-9.
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D'Amico AV, Whittington R, Malkowicz SB, Schnall M, Tomaszewski J, Schultz D, Kao G, VanArsdalen K, Wein A.
A multivariable analysis of clinical factors predicting for pathological features associated with local failure after radical prostatectomy for prostate cancer.
Int J Radiat Oncol Biol Phys. 1994 Sep 30;30(2):293-302.
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Epstein JI, Carmichael M, Partin AW, Walsh PC.
Is tumor volume an independent predictor of progression following radical prostatectomy? A multivariate analysis of 185 clinical stage B adenocarcinomas of the prostate with 5 years of followup.
J Urol. 1993 Jun;149(6):1478-81.
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Ferrari MK, McNeal JE, Malhotra SM, Brooks JD.
Vascular invasion predicts recurrence after radical prostatectomy: stratification of risk based on pathologic variables.
Urology. 2004 Oct;64(4):749-53.
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Karazanashvili G, Gadaleanu V, Ahlgren G.
Vascular invasion as a marker for prostate cancer recurrence after radical prostatectomy.
European Urology Supplements, Volume 1, Issue 1, January 2002, Pages 67.
Karazanashvili et al. conclude that patients with vascular invasion in the radical prostatectomy specimen are at high risk of recurrence after surgery, and that adjuvant systemic treatment should be considered for these patients. They further conclude that patients with negative surgical margins and no vascular invasion are likely to be cured by radical prostatectomy. (La Roca RL et al., 2014)

Linder BJ, Kawashima A, Woodrum DA, Tollefson MK, Karnes J, Davis BJ, Rangel LJ, King BF, Mynderse LA.
Early localization of recurrent prostate cancer after prostatectomy by endorectal coil magnetic resonance imaging.
Can J Urol. 2014 Jun;21(3):7283-9.
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Salomon L, Levrel O, Anastasiadis AG, Irani J, De La Taille A, Saint F, Vordos D, Cicco A, Hoznek A, Chopin D, Abbou CC.
Prognostic significance of tumor volume after radical prostatectomy: a multivariate analysis of pathological prognostic factors.
Eur Urol. 2003 Jan;43(1):39-44.
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Viers BR, Sukov WR, Gettman MT, Rangel LJ, Bergstralh EJ, Frank I, Tollefson MK, Thompson RH, Boorjian SA, Karnes RJ.
Primary Gleason Grade 4 at the Positive Margin Is Associated with Metastasis and Death Among Patients with Gleason 7 Prostate Cancer Undergoing Radical Prostatectomy.
Eur Urol. 2014 Jul 19. pii: S0302-2838(14)00632-0. doi: 10.1016/j.eururo.2014.07.004. [Epub ahead of print]
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